Spoiler for New Scientist Enigma 1749: “Genotype” (Follow the link to see the puzzle.)
This is pretty easy. Writing it as a multiplication and filling in the numbers we’re already given we have
9E0 x E9IGMA = 5CIE9TI5T
The left side is a multiple of 10, so the right side is too: T = 0:
9E0 x E9IGMA = 5CIE90I50
or, dividing by 10,
9E x E9IGMA = 5CIE90I5
Now either E or A (or both) must be 5, and the other must be odd; but to get 5 as the first digit on the right E must be 5:
95 x 59IGMA = 5CI590I5
and whatever IGMA is, 95 x 59IGMA is between 5605000 and 56999905 so C is 6:
95 x 59IGMA = 56I590I5
Of the 10 possibilities for I, only one makes 56I590I5 a multiple of 95: I = 3, with 56359035/95 = 593253.
So G = 2 and GENETICS = 25950365.